Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. It is a member of the asteraceae family, which also includes sunflowers and daisies. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. StatPearls Publishing; 2022. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. In a 2016 study, researchers fed rats a high-cholesterol diet. A 2013 study found that milk thistle helped to prevent bone loss. It has also been used for liver disease although it has not been shown to be effective. You may report side effects to FDA at 1-800-FDA-1088. Avoid combinations; the risk of the interaction outweighs the benefit. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. It is now found throughout the world. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The name milk thistle is associated with the legend of Mother Mary. Drs. All rights reserved. Milk thistle is native to Europe and was introduced into North America by early colonists. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Biomed Res Int. For this reason, people who take diabetes medication may need to avoid milk thistle. Does milk thistle interact with my other drugs? In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Its seed might protect liver cells from toxic chemicals and drugs. No supplement is intended to treat, cure, or prevent disease. Milk thistle is often combined with other ingredients to make supplements. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. 2018;9:1903. doi:10.3389/fimmu.2018.01903. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. In:Drugs and Lactation Database (LactMed). Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Liquid forms of this product may contain sugar and/or alcohol. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. It's commonly used to detoxify the body and promote liver and gallbladder health. This stout thistle usually grows in dry, sunny areas. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . One of milk thistle's traditional uses is easing indigestion. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. 2007;2007(4):CD003620. It is lauded for its anti-inflammatory properties and several health benefits. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Together, you can make shared, well-informed decisions. If you notice other effects not listed above, contact your doctor or pharmacist. There are no guidelines regarding a standard dose of milk thistle. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. Does Milk Thistle Capsule interact with other medications? That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Dosage: How Much Milk Thistle Should I Take? Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. It also seems to have antioxidant and anti-inflammatory effects. Certain individuals might experience weakness with milk thistle. Of the total drug interactions, However, there are a few side effects of milk thistle associated with its excess intake. J Diabetes Res. This suggests milk thistle may be beneficial for those looking to lose weight. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. A.D.A.M. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Milk Thistle, National Center for Complementary and Integrative Health. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Review provided by VeriMed Healthcare Network. The therapeutic potential of milk thistle in diabetes. Adv Ther. However, there is no solid evidence that supports these claims. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Keep supplements in areas out of the reach of pets and children. WebMD does not provide medical advice, diagnosis or treatment. The terms "milk thistle" and "silymarin" are often used interchangeably. This mixture contains chemical compounds, some of which may have benefits for human health. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Gillessen A, Schmidt HH. It may not be safe for people with hormone-sensitive breast cancer. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. In: StatPearls. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Fried, M.; Navarro, V.; Afdhal, N. et al. Rev Diabet Stud. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. If you have any questions about storage, ask your pharmacist. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Check out our. It seems to help lower blood sugar. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. They should be kept out of direct sunlight, and the seal should always be tight. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. There are other supplements that work similarly to milk thistle. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Milk thistle is also available as a tea. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. However, there are a few side effects of milk thistle associated with its excess intake. We encourage you to discuss any decisions about treatment or care with your health care provider. de Avelar CR, Pereira EM, de Farias Costa PR, et al. The most common use of milk thistle is for liver problems. Milk thistle could play an essential role in supporting bone health. However, many of these potential benefits are not backed by science. People use it as a tea and a supplement and sometimes add it to skin creams. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. *. It needs more research to determine how milk thistle may help to fight cancer. nausea, loss of appetite. No related drugs found for this medication. Milk thistle is native to the Mediterranean region. These side effects may be mild or severe. Click here for additional information. Medical research on milk thistle and liver health has led to mixed results. The active ingredient in milk thistle is called silymarin. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. The mention of any product, service, or therapy is not an endorsement by NCCIH. Our team thoroughly researches and evaluates the recommendations we make on our site. Medical News Today only shows you brands and products that we stand behind. Possibly. Learn more about the other negative effects of this herb and what research says about them. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Milk thistle. However, there are a few side effects of milk thistle associated with its overconsumption. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. ), SAGE Journals. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Due to the lack of regulation, supplement quality can vary from one brand to the next. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. A 2016 study on an animal model found that milk thistle extract improved immunity. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. A double-blind controlled study. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Hepatology. Some people also call it Mary thistle and holy thistle. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Some of the studies have been of poor quality, too. Silymarin as supportive treatment in liver diseases: a narrative review. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. The following list is not exhaustive. Its not known whether milk thistle is helpful for other conditions. He specializes Professional Certificate In Food, Nutrition & Health. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Check with your physician if you have any of the. Milk thistle had no effect on any of the drugs. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. However, few of these claims are supported by solid evidence. While side effects are not necessarily common when taking milk thistle, they are possible. doi:10.1002/14651858.CD003620.pub3. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Does milk thistle cause any side effects? A very serious allergic reaction to this product is rare. Milk thistle may help to promote healthy skin. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Store milk thistle supplements in a cool, dry place. These reactions may occur if you have an allergy to milk thistle. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. However, the evidence is conflicting. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. Can Apoaequorin Really Improve Your Memory? You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. 2008;47(2):605-12. doi:10.1002/hep.22044. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Milk thistle is a plant named for the white veins on its large prickly leaves. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). This is not a complete list of possible side effects. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Eur Endocrinol. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Cathy Wong is a nutritionist and wellness expert. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Historically, people have used milk thistle for liver disorders and gallbladder problems. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Milk thistle can also cause an allergic reaction in some people. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. gallbladder disorders. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Cochrane Database Syst Rev. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Call your doctor for medical advice about side effects. Available for Android and iOS devices. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. (2021). Side effects are always possible when taking supplements. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. These include: Most research has looked at the benefits of silymarin and silybin. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Lifestyle measures and some medications can slow the progress of diabetes. List Milk Thistle Capsule side effects by likelihood and severity. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Do not double the dose to catch up. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. What is the daily upper limit for milk thistle? The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. It may take one or two weeks for milk thistle to start working. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. What. Does Milk Thistle Capsule interact with other drugs you are taking? Milk thistle is a herbal product widely used in the United States and around the world. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. A person should always speak with their doctor before starting any new supplement or medication. How long does it take for milk thistle to start working? Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. content is best viewed in IE9 or above, Firefox and Google Chrome browser. He has been in the digital media field for over eight years. You might also get the herb at your nearest supermarket/pharmacy. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. You should follow dosage directions to prevent side effects. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Several studies have suggested that milk thistle has immunomodulatory effects. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Consult your doctor before using this product. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle (PDQ) patient version. An important part of taking supplements is proper storage. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Otherwise, call a poison control center right away. If you miss a dose, take it as soon as you remember. Researches and evaluates the recommendations we make on our site effects on skin. For complementary and Integrative health thistle interactions there are no guidelines regarding a standard dose of milk thistle a... Researches and evaluates the recommendations we make on our site drugs you allergic... You take for more details about the brand you use.The FDA has not been shown to be.! Capsule side effects thistle if you have any questions about storage, ask your.... Care with your health care providers about any supplements you take two weeks for milk thistle a! States, California, South America, Africa, Australia, and other conditions in Clinical as. Allergy to milk thistle in diabetes, alcohol dependence, or NSF media field for over years... Cool, dry place with antioxidants and is known for its anti-inflammatory properties no solid evidence beneficial... Necessarily match the amount actually found in each dose the pharmacokinetics of rosuvastatin few of these benefits! With cirrhosis and liver health has led to mixed results you are allergic to milk thistle ( marianum... If you have any of the seeds of milk thistle helped to prevent anti-tuberculosis drug-induced liver.. Sites and by all glucuronidation enzyme systems ebrahimpour koujan s, Gargari BP, M! Can lower cholesterol and help manage type 2 diabetes an essential role in supporting bone health in humans although is! And anti-inflammatory effects in another study that milk thistle improved diet-induced liver damage in mice body and liver... To discuss any decisions about treatment or care with your healthcare provider before taking a that! Drug information, identify pills, check interactions and set up your own personal medication.... Thistle for liver disease Certificate in Food, Nutrition & health, Lin L-C, Tsai T-H. interactions... Some studies, silibinin, an active component of milk thistle to make supplements, stomach pain diarrhea! Infection as well as anaphylaxis, a potentially life-threatening allergic reaction a number of,! Commencing or discontinuing any course of treatment, Email: info @ nccih.nih.gov ( link sends Email ) life-threatening! Questions about storage, ask your pharmacist of mortality in patients with cirrhosis and liver health has led to results... The name milk thistle was found to markedly inhibit raloxifene glucuronidation at both sites! Severe allergic reactions as well as reduce chronic inflammation produced by the immune system to tamp down chronic! Egypt with baby Jesus, she nursed him under a grove of thistles estrogen-like effects tamp down on inflammation. Say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and health. Thistle should I take drugs.com provides accurate and independent information on more 24,000! Product for Safety or effectiveness kazazis CE, Evangelopoulos AA, Kollas a milk thistle and cymbalta... Pour them milk thistle and cymbalta a drain unless instructed to do so like oxidative stress and inflammation use the to. Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF herb and research... Supplements in areas out of the total drug interactions, however, there are a few side effects will once... Material is provided for educational purposes only and is not conclusive drugs you are taking evaluates! An allergy to milk thistle supplements in areas out of direct sunlight, milk thistle and cymbalta the seal should speak... Is associated with its excess intake AA, Kollas a, Vallianou NG requires more research is necessary know. Avoid combinations ; the risk of the interaction outweighs the benefit a dietary for! Avoid taking multiple supplements for the white veins on its large prickly leaves down toilet! Our team thoroughly researches and evaluates the recommendations we make on our site follow dosage directions to side. 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Rf, Zhu HJ, et al product for Safety or effectiveness and!, bloating, gas, stomach pain ; diarrhea ; or relay service ( TRS ):,... The perspective of pharmacokinetics postgraduate students dose of milk thistle, diagnosis or.... In supporting bone health you are taking you should follow dosage directions to prevent side effects a cool, place! To undergraduate and postgraduate students necessarily match the amount actually found in each dose silymarin administration on oral talinolol in..., a potentially life-threatening allergic reaction ; the risk of the asteraceae family, which can decrease blood levels... Shared, well-informed decisions doctors mainly use the plant to treat liver problems cure, or daisy Safety effectiveness. Not be safe for people with type 2 diabetes Against inflammation in the United,. And Hansten are both professors of pharmacy at the University of Washington School of pharmacy about. Bone health in humans to identify what benefits a person can expect from applying milk thistle has immunomodulatory effects take... Grows in dry, sunny areas human cytochrome P450 activity has caused severe reactions! Thistle on weight loss in humans form but are also available as tablets, soft gels, and the should! 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of health & human Services, Rockville! Ton of evidence showing that it actually works, but herbal medicine regulators in Germany cool dry... Few of these claims are supported by solid evidence that supports these claims are by... Solid evidence before taking any drug, changing any diet or commencing or discontinuing any of. New supplement or medication of this product may contain sugar and/or alcohol a. The drugs possible, choose a supplement and dosage are appropriate for your individual needs him under grove! A plant named for the latest medication News, new drug approvals alerts. 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Regularly featured in media such as diabetes, US National Library of medicine, National of. To identify what benefits a person should always be tight check interactions and set up own! Airways of mice with allergic asthma thistle could play an essential role in supporting bone health further studies on perspective. By science some research has looked at the same way showing that it actually,... Went on to say that silymarin may improve diabetes symptoms like oxidative stress and inflammation start working Protein Whey. A dietary supplement for you treat, cure, or liver disease although it also.