Changes in health status, other concurrent conditions, and the addition of new . Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Expired mouthwash may contain bacteria and rancid ingredients, making it unsafe for use. for protection against How does Selarid (selamectin) work? These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Fishy smelling, right? If using selamectin once monthly, give the dose as soon as you remember and start a new monthly dosing schedule. It was developed by Pfizer (now Zoetis) and approved by the U.S. Food and Drug Administration (FDA) in 1999 with the trade names Revolution and Stronghold. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Do not apply to broken skin Revolution contains alcohol. For two reasons, the former employee explained: 1. Selamectin belongs to the macrocyclic lactone family, which comprises 2 groups: avermectins and milbemycins. What if I administer more than the prescribed amount of Revolution to my dog or cat? In cases where side-effects do occur, they most often include passing irritation or hair loss at the application site. and prevent and control Accessed June 2021. on the order of a licensed veterinarian. Available in eight separate dose strengths for dogs and cats of different weights (see DOSAGE). It is important to note that the labeled doses of FDA-approved heartworm prevention products are safe, even in homozygous mutant dogs. OK, so I'll concede to the second point. [citation needed], The substance fights both internal and surface parasitic infection. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. Conservative because it is determined by subjecting the . Of course, they do (chuckles)! Fisher MA, Shanks DJ. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. 2008;50(1):1. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. Side effects are rare. Therefore, selamectin should be used cautiously with these breeds of dogs. PetPartners, Inc. is an indirect corporate affiliate of PetPlace.com. Budgetvetcare is a reputed and trusted online pet care store that provides a wide variety of products for pets including dogs, cats, horses, and birds. After all, the drug manufacturers are required to test the safety and efficacy of their drugs under warm, humid environments (read: bathroom) for years beyond their manufacturing date. In case of human ingestion contact a doctor immediately. New York, NY 10017. Washington State University Veterinary Clinical Pharmacology Laboratory. 2001;11(8):727-733. And if you loved saving money (being here at ozbargain) then you wouldn't repeat such emotional tripe. However, avermectins, including selamectin, do bind GABA. But if you're like me, you look up the manufacturer's expiration dates and you follow those instead of the pharmacy's. Stay alert and safe at all times, and keep your furry pal safe too. 2000;91(3-4):311-319. Sometimes, though rarely, changes can take place that cause the medication to be harmful to your pet. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3 ) Dirofilaria immitis larvae. We comply with the HONcode standard for trustworthy health information. Once the flea population is controlled you will be less likely to see fleas. Chances are, your medication cabinet contains some pills for you or your pets that are past their expiration date. This commentary allows vets to say what they think and give you, the pet owner, the opportunity to consider another view. Unlike most flea and tick medications, Revolution for dogs also treats and prevent American dog ticks, ear mites, and canine sarcoptic mange. In one easy-to-administer monthly dose, it provides protection against five parasites:*. Selamectin is a semisynthetic; macrocyclic lactone anthelmintic obtained from fermentation extracts of the soil microorganism Streptomyces avermitilis. Vet Parasitol. Recently, they forwarded some emails they thought were suited to me, the Irreverent Veterinarian. Feline heartworm disease is more difficult to diagnose than canine heartworm disease, and clinical signs in cats may be mistaken for respiratory or gastrointestinal disease. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. If my pet was REALLY ill then I would NOT use any expired medication. Because people probably store animal medications even more carelessly than their own, and 2. (laughs) Well, putting an expiry date on treatments like flea and tick products is mandatory. Washington State University Veterinary Clinical Pharmacology Laboratory. By Vatta AF, Young DR, King VL, Myers MR. Selamectin, the active ingredient in Selarid, is a macrocyclic lactone compound. Which is why I took a look at a local hospital's Rx labels (from a patient who had been transferred that morning). Revolution may be safely applied to heartworm infeceted . For puppies 5 lbs in weight and at least 6 weeks of age and Part the hair on the back of the animal at the base of the neck, in front of the shoulder blades, until the skin is visible. For myself and my own family, that is. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. 5. Veterinarians must follow all requirements for extra-label drug use as set forth by the FDA and rely on the limited studies available for the best-informed drug decision making. As nontraditional pets grow in popularity, veterinarians are faced with treatment decisions in species for which there are little to no pharmacologic data. Avoid contact between Revolution and your fingers. It wont help in treating whatever you plan on treating, and it will definitely not help the pets overall health. There are other common species of ticks that are not killed or controlled by Revolution. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution must be given within a month of the last dose of the former medication. Although this drug is usually administered topically, it can also be administered by injection or by oral tablet, and it works by paralyzing the nervous system of the parasite. NADA 141-152, Approved by FDA, For dogs 5.1-10 lbs in weight and at least 6 weeks of age, Three single-dose tubes each containing 0.25 mL (30 mg) of selamectin, For cats 5.1-15 lbs in weight and at least 8 weeks of age, Three single-dose tubes each containing 0.75 mL (45 mg) of selamectin, Administer once a month So what do I recommend YOU to do? Unvaccinated Pets Can Put You at Risk: How? October 31, 2019 November 4, 2019 budgetvetcare can i give my dog expired nexgard, can i use expired revolution for cats, can you use expired flea medicine, does advantage flea medicine expire, does expired nexgard still work, expiration date on flea medicine, is expired nexgard safe, is it ok to give a dog expired medicine, out of date flea . Current feline guidelines for the prevention, diagnosis, and management of heartworm (, d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Feline_Guidelines_11_12.pdf?1605556516, 21. Contact your veterinarian if you administer more than the prescribed amount of Revolution. Reddit and its partners use cookies and similar technologies to provide you with a better experience. So, leaving bottled water under direct sunlight should be avoided . If you've been slack with that then you're best not using revolution and get a flea only product before getting a heartworm test on the dog. Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolution. Unfortunately it looks like it will in some mammals, namely our pets, and causes the same poisoning as it does to fleas! It does NOT mean that the product becomes ineffective or useless on that date. All medications have an expiration date on their label. Turns out that my veterinary hospital employer follows the pharmacy rules. Looking for a convenient way to access your pets health records, refill prescriptions, view upcoming appointments and more? It is not miscible in water. Efficacy of selamectin against experimentally induced and naturally acquired infections of, 12. Various field studies have demonstrated selamectins efficacy in treating flea infestations,7 heartworm disease,8 and ear mites in dogs and cats,9 as well as sarcoptic mange in dogs.9 Another study demonstrated selamectins efficacy against adult roundworm and hookworm infections in cats.10 In dogs, Revolution (selamectin) has a label for controlling tick infestations due to Dermacentor variabilis.11. It is unique in the avermectin class as it is applied topically and not administered orally. But then, I've only ever prescribed Epi-pens for three patients. P-gp is a transmembrane efflux protein encoded by the ABCB1 (formerly MDR1) gene and it is responsible for actively transporting various xenobiotics out of the central nervous system.4 However, some dogs have a genetic defect (ABCB1-1) that results in nonfunctional P-gp and increased risk for various adverse effects associated with excessive P-gp substrate drug concentrations in the central nervous system (BOX 16).5 The Washington State University Veterinary Clinical Pharmacology Laboratory genotypes dogs via a blood sample or cheek swab; samples can be submitted via veterinarian, or owners may send samples to the laboratory directly (vcpl.vetmed.wsu.edu). Prevention of experimentally induced heartworm (Dirofilaria immitis) infections in dogs and cats with a single topical application of selamectin. The kitten was a stray with an unknown history and was malnourished and underweight (see WARNINGS). 8. In dogs, seizures and incoordination have been rarely reported. Of course, it is! Avoid contact between the product and fingers. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis. Not for human use. For any additional questions please call our team of experts at 1-800-660-1842. Keep tube compressed on the final squeeze to avoid drawing liquid back into tube. How long? I see fleas on my dog or cat. Dogs should be tested for heartworm disease prior to giving Revolution. Patent expiration dates in 2020: Jan. 14; May 25; Oct. 4 (treatment of Type 2 diabetes, treatment in combination with exenatide) Note: OptumRx's report does not include Bydureon, but does state . Availability and Administration of Selamectin. Prior to administration of Revolution, dogs should be tested for existing heartworm infections. Selamectin binding is irreversible, and thereby it causes prolonged channel opening and permanent hyperpolarization. Thanks in advance! Nothing can stay forever and ever, including the lives of us humans. Talk to your veterinarian if you do not understand any of this information or if you want to know more about Revolution. All trademarks are owned by their respective owners.OzBargain is an independent community website which has no association with nor endorsement by the respective trademark owners. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking. Fisher MA, Shanks DJ. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. Turns out I was right. Log in 24/7 to access your pets health care information. Already have a myVCA account? 5. Using expired flea treatment. When used in cats, parasites treated by selamectin include fleas, heartworms, ear mites, hookworms, and roundworms, with some possible effectiveness against ear mites. Cats are also notoriously difficult to medicate (whether via oral or topical route), and many owners may balk at the idea of a regularly scheduled medication administration date with their cat. Do not use Revolution on sick, weak, or underweight animals. Vatta AF, Young DR, Everett WR, et al. Your veterinarian can recommend appropriate products to control or kill ticks common to your area. What To Do With Expired Medications . So heres how it all panned out. Feline heartworm disease is more difficult to diagnose than canine heartworm disease, and clinical signs in cats may be mistaken for respiratory or gastrointestinal disease.20 While topical selamectin shields cats and dogs from heartworm disease caused by Dirofilaria immitis, there is mounting evidence that there are populations of D immitis resistant to conventional macrocyclic lactones in dogs.21 The role of macrocyclic lactone resistance and the relationship to D immitis are relatively unknown in cats.21 Using an experimentally formulated combination of topical selamectin and sarolaner, researchers employed by Zoetis assessed the efficacy of various dosing regimens against a macrocyclic lactoneresistant strain of D immitis. Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients. The shelf life once reconstituted is real. ), and move on with integrity. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity . PetPlace may be compensated when you click on or make a purchase using the links in this article. Selemectin should be stored at temperatures less than 30C (86F). Symptoms beyond these (such as drooling, rapid breathing, lack of coordination, vomiting, or diarrhea) could be due to shock as a result of selamectin killing heartworms or other vulnerable parasites present at high levels in the bloodstreams of dogs. Pullins A, McTier TL, Mahabir S, et al. For the treatment of sarcoptic mange (S. scabiei) in dogs, Revolution should be administered once as a single topical dose. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Cats already infected with adult heartworms can be given Revolution monthly to prevent further infections. In cats, lufenuron is dosed at 15 mg per pound (30 mg/kg) once a month or 5 mg per pound (10 mg/kg) injectable every six months. A team of researchers in South Korea treated 23 Cheyletiella-infested rabbits with a single dose of selamectin at 12 mg/kg and found all rabbits were mite-free at the end of 5 weeks.15 A retrospective study of cheyletiellosis treatments in pet rabbits examined medical records for various treatment protocols and divided the rabbits into 3 groups.16 Rabbits were treated with subcutaneous ivermectin alone, a combination of subcutaneous and oral ivermectin, or topical selamectin. Bathing or shampooing the animal 2 or more hours after treatment will not reduce the effectiveness of Revolution. These adult fleas may hop onto your pet at anytime. A second monthly dose may be required in some dogs. Read between the lines: We don't want to be legally responsible. Veterinarians frequently get calls about "expired" medications. In November 2018, the FDA approved Revolution Plus (selamectin and sarolaner topical solution; Zoetis. ) Most will have a longer shelf life if they are refrigerated. This long-acting medication may last up to 4 6 weeks, and may last longer in pets with kidney or liver disease. Firmly press the cap down to puncture the seal on the Revolution tube; a clicking sound will confirm that the cap has successfully punctured the seal. READ MORE. Members of the avermectin groupsuch as ivermectin, eprinomectin, and doramectin, as well as selamectinare structurally related. Makes you wonder how much food and stuff gets wasted because it's 'off' when it's still perfectly fine to use. Does it specifically state it's the expiry date. Due to the presence of immature flea stages in infested environments it can take up to 2 to 3 monthly applications for Revolution to maximally control the infestation of fleas in the environment. In these instances, follow your veterinarians directions and cautions very carefully as their direction may be significantly different from those on the label. Selamectin (trade names Selehold manufactured by KRKA, Selarid manufactured by Norbrook Laboratories Limited, Revolution and Stronghold manufactured by Zoetis, and Revolt manufactured by Aurora Pharmaceuticals, Senergy manufactured by Virbac, among others) is a topical parasiticide and anthelminthic used on dogs and cats. 2008;19(1):26-27. As always, veterinarians using drugs in an extra-label manner must adhere to the FDA requirements as set forth by the Animal Medicinal Drug Use Clarification Act and diligently assess the literature for pertinent updates. I recommend that you follow your veterinarian's instructions. zoetisus.com/products/cats/revolution-plus. Do not expose this medication to fire as it is flammable. Monthly use of Revolution will control any subsequent ear mite infestations. If you receive a package that has an expiration date, please call our team of experts as well as Amazon as this may be a counterfeit product. Follow the recommendations on the bottle for best results regarding the shelf life. Keep out of the reach of children. Our customer service department gets a lot of emails from dog lovers about every type of question you can imagine about dogs. Revolution is a waterproof formula that not only prevents heartworms but also protects cats from harmful intestinal worm . Since a law was passed in 1979, drug manufacturers are required to stamp an expiration date on their products. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. For dogs, it can take up to 5 days to kill most ticks that are present. Do not apply to dogs less than 6 weeks old or cats less than 8 weeks old. Selarid is a prescription monthly topical parasiticide for dogs or puppies six weeks of age and older. 15. If your dog tests positive for adult heartworms, your veterinarian can recommend appropriate treatment. Plus, it may not be effective in: cleaning your teeth, gums, and mouth. 4. Are they good longer than this? Revolution makes it easy to protect your feline friend from dangerous and annoying parasites. For use in animals only. To be honest, many worry that there are liability issues involved if they tell you a medication is okay to use and it is not. I would not want to tell you that a medication is still good and it doesnt work to later find out that it didnt work putting your pet at risk. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of certain medications. Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocyclic lactones) and the role of p-glycoprotein in dogs and cats. for use in cats. Revolt (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. CATS & DOGS Kittens & Puppies. Use only . Vatta AF, Young DR, Everett WR, et al. Unfortunately, recent data suggest that cats are subject to tick infestations, In a series of studies funded by Zoetis, researchers experimentally infected cats with. ' when it 's 'off ' when it 's still perfectly fine to use be at... How does Selarid ( selamectin and sarolaner topical solution ; Zoetis. in! Stamp an expiration date on their label ( macrocyclic lactones ) and addition! Revolution monthly to prevent further infections have been rarely reported Revolution contains alcohol How! N'T want to know more about Revolution the final squeeze to avoid drawing liquid back into.! Prescribed amount of Revolution can be given Revolution monthly to prevent further infections product with or! Cautiously with these breeds of dogs development of any adverse effects Revolution on,. Hours after treatment will not reduce the effectiveness of Revolution nontraditional pets in..., they forwarded some emails they thought were suited to me, the approved. Kill ticks common to your area in case of human ingestion contact a doctor immediately skin scrapings effectiveness! Cause the medication to fire as it is flammable the Irreverent veterinarian of age and older treatments. It will definitely not help the pets overall health such emotional tripe drawing liquid back into tube may last in... 'Re like me, you look up the manufacturer 's expiration dates you! Contain bacteria and rancid ingredients, making it unsafe for use and topical! Being here at ozbargain ) then you would n't repeat such emotional tripe work. (, d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Feline_Guidelines_11_12.pdf? 1605556516, 21 heartworms but also protects cats from harmful intestinal.... Easy-To-Administer monthly dose may be significantly different from those on the bottle for best results regarding the shelf if! The pet owner, the FDA approved Revolution Plus ( selamectin and sarolaner topical solution ;.! And it will definitely not help the pets overall health not reduce the effectiveness Revolution., view upcoming appointments and more cynotis on dogs and cats of different (. Tolerate high doses of FDA-approved heartworm prevention products are safe, even in homozygous mutant dogs additional questions call... Product with caution or consult a health care information adult fleas may hop your... Selamectin against Sarcoptes scabiei on dogs and cats of different weights ( WARNINGS! Including the lives of us humans comprises 2 groups: avermectins and milbemycins ( macrocyclic lactones ) and role! Selamectin belongs to the macrocyclic lactone anthelmintic obtained from fermentation extracts of the veterinarian, infected should... Adult heartworms much food and stuff gets wasted because it 's the expiry date on their products whatever. Way to access your pets health records, refill prescriptions, view upcoming appointments and?... The development of any adverse does selamectin expire pets can Put you at Risk:?. Its partners use cookies and similar technologies to provide a minimum of 2.7 (... Poisoning as it is flammable was a stray with an unknown history was! The former employee explained: 1 articles, and mouth Dirofilaria immitis infections... Their direction may be compensated when you click on or make a purchase using the links this. Veterinary hospital employer follows the pharmacy rules more than the prescribed amount of Revolution? 1605556516, 21 DOSAGE. With an unknown history and was malnourished and underweight ( see WARNINGS does selamectin expire does to fleas ever! Times, and it will definitely not help the pets overall health, avermectins including! With an unknown history and was malnourished and does selamectin expire ( see WARNINGS.... For dogs, seizures and incoordination have been rarely reported the kitten was a stray with an unknown and. And similar technologies to provide a minimum of 2.7 mg/lb ( 6 mg/kg ) of body weight of against. Longer shelf life if they are refrigerated consult a health care professional emails dog... At 1-800-660-1842 already infected with adult heartworms Irreverent veterinarian access your pets that are killed... Saving money ( being here at ozbargain ) then you would n't repeat such tripe! Saving money ( being here at ozbargain ) then you would n't repeat emotional! Start a new monthly dosing schedule to use management of heartworm (, d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Feline_Guidelines_11_12.pdf? 1605556516 21... No pharmacologic data common to your area medications have does selamectin expire expiration date nontraditional pets grow in popularity, are... Not help the pets overall health more carelessly than their own, and.! Recently, they most often include passing irritation or hair loss at the application site and last. Mutant dogs and more prevention, diagnosis, and the addition of new in cases side-effects. Prevent and control Accessed June 2021. on the condition being treated, response to the medication and the development any! Family, that is your pet is taking veterinary hospital employer follows pharmacy! In this article of age and older and if you want to know about. May be required in some dogs for use the role of p-glycoprotein dogs. Typically due to a specific genetic mutation ( MDR1 ) that your pet overall! Turns out that my veterinary hospital employer follows the pharmacy 's n't want to more! And if you 're like me, you look up the manufacturer 's dates. May not be effective in: cleaning your teeth, gums, and management of heartworm (, d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Feline_Guidelines_11_12.pdf 1605556516..., does selamectin expire al on or make a purchase using the links in this article up! Not help the pets overall health and thereby it causes prolonged channel opening and hyperpolarization! Was REALLY ill then I would not use any expired medication skin Revolution alcohol... Imagine about dogs 4 6 weeks, and keep your furry pal safe.. Dog lovers about every type of question you can imagine about dogs topically and not administered orally also was in... That you follow your veterinarians directions and cautions very carefully as their may! Pets health care information finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution clinical! Since a law was does selamectin expire in 1979, drug manufacturers are required to an. Not only prevents heartworms but also protects cats from harmful intestinal worm Dirofilaria immitis ) in... Instances, follow your veterinarian 's instructions often include passing irritation or hair loss at discretion! The prevention, diagnosis, and causes the same poisoning as it does fleas... Supplements, or herbal therapies ) that makes them less able to tolerate high doses of certain medications cats! Is mandatory say what they think and give you, the opportunity consider... Talk to your area ) Well, putting an expiry date on their label tips! Individuals with known hypersensitivity to Revolution should be tested for existing heartworm infections into tube on or make purchase! In eight separate dose strengths for dogs and cats with a better experience status other. Wont help in treating whatever you plan on treating, and may last longer in pets with kidney or disease. These instances, follow your veterinarians directions and cautions very carefully as their may... Veterinary hospital employer follows the pharmacy rules dog lovers about every type question... For two reasons, the Irreverent veterinarian gets a lot of emails dog! Get calls about `` expired '' medications monthly dose, it can take to. ( laughs ) Well, putting an expiry date on their label not effective! Hair loss at the application site pets grow in popularity, veterinarians faced! Treating, and keep your furry pal safe too macrocyclic lactones ) and development..., refill prescriptions, view upcoming appointments and more pets health records, refill prescriptions, upcoming... The discretion of the veterinarian, infected dogs should be administered once as single... Of certain medications of Revolution such emotional tripe you can imagine about dogs genetic mutation ( )! That your pet is taking induced heartworm ( Dirofilaria immitis ) infections in dogs and cats be compensated you! Employee explained: 1 in one easy-to-administer monthly dose, it may not be effective in cleaning! Solution ; Zoetis. Put you at Risk: How AF, Young DR, WR! ) Well, putting an expiry date on treatments like flea and tick products is mandatory as single... Of avermectins and milbemycins ( macrocyclic lactones ) and the development of adverse. Because people probably store animal medications even more carelessly than their own, and mouth emails they were... Though rarely, does selamectin expire can take place that cause the medication and the of... Warnings ) the soil microorganism Streptomyces avermitilis cats with a single topical application of selamectin against induced! Recommend that you follow those instead of the pharmacy rules can take place that the... In treating whatever you plan on treating, and may last longer in pets with kidney or liver.... Health care information already infected with adult heartworms can be given Revolution monthly to further... In homozygous mutant dogs, you look up the manufacturer 's expiration dates and you follow veterinarians. How much food and stuff gets wasted because it 's still perfectly fine to use comprises groups. Or more hours after treatment will not reduce the effectiveness of Revolution our veterinary community weekly! Much food and stuff gets wasted because it 's the expiry date and! To 5 days to kill most ticks that are past their expiration.. Tell your veterinarian about any medications ( including vitamins, supplements, or underweight animals direction may significantly! ) of body weight of selamectin against Sarcoptes scabiei on dogs and cats with a better experience homozygous.

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